Sabres vs. Red Wings Prediction & Picks - Oct. 22

Toronto Maple Leafs v Detroit Red Wings

Photo: Nic Antaya / Getty Images Sport / Getty Images

The Buffalo Sabres (2-4) host the Detroit Red Wings (5-1, winners of five in a row) at KeyBank Center. The game on Wednesday, Oct. 22 begins at 7:30 p.m. ET on TNT.

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Ahead of watching this matchup, here is a glimpse at which club we predict will come out on top in Wednesday's action on the ice.

Sabres vs. Red Wings Predictions for Wednesday

Our computer projection model for this encounter predicts a final score of Red Wings 4, Sabres 3.

  • Moneyline Pick: Red Wings (-104)
  • Total Pick: Under 6 (computer predicts 5.6 goals on average)
  • Spread Pick: Red Wings (+1.5)

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Sabres Splits and Trends

  • In the two games this season the Sabres registered only one goal, they lost both times.
  • Buffalo has lost the only game this season when it scored two goals.
  • The Sabres have scored three or more goals two times, and are 2-0-0 in those games.
  • In games when it has outshot its opponent, Buffalo is winless (0-2-0).
  • The Sabres have been outshot by opponents four times, and went 2-2-0 (four points).

Red Wings Splits and Trends

  • The Red Wings have posted a record of 1-0-1 in overtime matchups to contribute to an overall mark of 5-1.
  • Detroit has won both of its games that were decided by one goal.
  • This season the Red Wings scored only one goal in one game and they lost that matchup.
  • Detroit has won the only game this season when it scored two goals (1-0-0, two points).
  • So far this season, the Red Wings have scored at least three goals four times and won each of those games.
  • This season, Detroit has scored a lone power-play goal in four games and picked up six points with a record of 3-1-0.
  • When it outshoots its opponent this season, Detroit has posted a record of 3-1-0 (six points).
  • The Red Wings have been outshot by opponents twice, and won both times.

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Team Stats Comparison

Sabres Rank Sabres AVG Red Wings AVG Red Wings Rank
28th 2.50 Goals Scored 3.33 9th
16th 3.00 Goals Allowed 2.33 7th
8th 29.7 Shots 26.8 19th
30th 33.3 Shots Allowed 25.2 7th
6th 26.32% Power Play % 22.22% 16th
2nd 95.83% Penalty Kill % 92.31% 4th

Sabres vs. Red Wings Game Time and TV Channel

  • When: Wednesday, October 22, 2025 at 7:30 p.m. ET
  • TV Channel: TNT
  • Live Stream: Watch this match on HBO Max (Regional restrictions may apply)
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)
  • Where: KeyBank Center in Buffalo, New York

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